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RESEARCH                                                                 

 

HIGHER DEGREE

 

Doctor of Philosophy

The Effects of SMA-Pirarubicin as a Selective Tumour Targeting Agent for the Treatment of Colorectal Cancer Liver metastases, PhD, University of Melbourne, 2011

Honours

Effect of Thalidomide on Colorectal Cancer Liver Metastases, BBiomed Sci Honours, University of Melbourne 2004

 

Research Associate - VERITAS - Victorian Collaborative for Education, Research, Innovation, Training and Audit by Surgical Trainees

INTERNATIONAL MULTICENTRE COLLABORATIVES 

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PUBLICATIONS

First Author

1.     Daruwalla J, Sachithanandan N, Andrews D & Miller, J. Ectopic intravagal parathyroid adenoma. Head and Neck, 37(12):200-

        204, 2015.

2.     Daruwalla J, Malcontenti Wilson, Muralidharan V & Christophi C. Styrene maleic acid copolymer–pirarubicin induces tumor-

        selective oxidative stress and decreases tumor hypoxia as possible treatment of colorectal cancer liver metastases. Surgery,

        158(1):236-247, 2015.

3.     Daruwalla J, Murray D, Pande G, An unusual case of small bowel obstrcution. ANZJS, 85(5):391-392, 2015

4.     Daruwalla J, Hadge A, Wen S & Nikfarjam M. High fat diet is not associated with stimulation of colorectal cancer liver

        metastases. World Journal of Surgical Research. 3:38, 2014.

5.     Daruwalla J, Maddern G. The effect of fatigue on simulated laparoscopic surgical skills: a comparative historical control

        cohort study. ANZ Journal of Surgery. 84:137–142, 2014.

6.     Daruwalla J, Malcontenti Wilson, Muralidharan V, Maeda H & Christophi C. In vitro and in vivo evaluation of tumor targeting 

        SMA- pirarubicin micelles: Survival improvement and inhibition of liver metastases. Cancer Science. 101(8):1866-1874,

        2010. Figure 7 used - Front Cover of issue (see background).

     

7.     Daruwalla J, Greish K, Malcontenti-Wilson C, Muralidharan V, Iyer A, Maeda H, Christophi C. Styrene maleic acid-pirarubicin

        disrupts tumor microcirculation and enhances the permeability of colorectal liver metastases. Journal of Vascular                          Research. 46 (3): 218-228, 2009.

8.     Daruwalla J, Greish K, Malcontenti-Wilson C, Muralidharan V, Maeda H & Christophi C. SMA-pirarubicin induces tumor                    selective oxidative damage and reduces tumor hypoxia. Annals of Oncology. 18 (VII34-VII34), 2007.

9.     Daruwalla J, Nikfarjam M, Greish K, Malcontenti Wilson, Maeda H & Christophi C. Evaluation of the effect of SMA-pirarubicin

        micelles on colorectal cancer liver metastases and of hyperbaric oxygen in CBA mice. Journal of Drug Targeting. 15(7-8):

        487- 495, 2007.

 

10.   Daruwalla J, Malcontenti Wilson, Maeda H & Christophi C. Hyperbaric oxygen therapy for malignancy: A review. World

         Journal of Surgery. 30(12): 2112-2131, 2006.

11.   Daruwalla J and Christophi C. The effect of hyperbaric oxygen therapy on tumour growth in a mouse model of colorectal

        cancer liver metastases. European Journal of Cancer. 42(18): 3304-3311, 2006

12.   Daruwalla J, Greish K, Nikfarjam M, Malcontenti-Wilson C, Maeda H & Christophi C. SMA-pirarubicin inhibits growth of                     colorectal cancer liver metastases in an animal model. Cancer Research. 66 (8): 721, 2006.

 

13.   Daruwalla J, Nikfarham M, Malcontenti Wilson, Fanartzis M & Christophi C. Effect of thalidomide on colorectal liver

        metastases. Journal of Surgical Oncology. 91(2): 134-140, 2005.

Co-Authored
 

1.    Pre-and Post-treatment predictive models of peritoneal recurrence after FLOT-chemotherapy and surgery: An international           study," JCO Precision Oncology, May 2026.

2.    Total versus subtotal gastrectomy following neoadjuvant FLOT chemotherapy for distal diffuse gastric adenocarcinoma: An           international cohort study. Gastric Cancer, April 2026

3.    Open versus hybrid and total minimally invasive transthoracic Ivor Lewis oesophagectomy following neoadjuvant FLOT                chemotherapy: An Australian and New Zealand Cohort Study, WJS, 2026.

4.    Luo F, Daruwalla J et al., Early drain colour change for the detection of clinically relevant post‐operative pancreatic                          fistula. Surgical Practice, 2025

5.    Pathological response guides adjuvant FLOT chemotherapy in surgically resected gastroesophageal cancer (SPACE-FLOT): An        international cohort study, BJS , 2025

6.   Yoshino O, Daruwalla J et al., A new technique for spleen preserving distal pancreatectomy. Which is more critical, inflow or          outflow, DDW, 2024

7.    POSTVenTT Collaborative. Postoperative anaemia increases unplanned readmission: an international prospective cohort              study of patients undergoing major abdominal surgery, BJS, 2024.

 

8.    POSTVenTT International Collaborative. Postoperative variations in anaemia treatment and transfusions (POSTVenTT):                  protocol for a prospective multicentre observational cohort study of anaemia after major abdominal surgery. Colorectal              Disease, 2022.

 

9.    COVIDSurg Collaborative*. Elective surgery system strengthening: development, measurement & validation of Surgical                  Preparadness Index (SPI) across 1632 hospital, 119 countries. Lancet 2022

 

10.  COVIDSurg Collaborative*. SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective           cohort study. Anaesthesia, doi: 10.1111/anae.15563, August 2021.  

 

11.  COVIDSurg Collaborative*. Resilience of elective cancer surgery systems during COVID-19 lockdowns: International,                       prospective cohort study of planned surgery for 15 tumour types in 61 countries Annals of Oncology, 33 (5), August 2021. 

 

12.  COVIDSurg Collaborative and GlobalSurg Collaborative*. SARS-CoV-2 vaccination modelling for safe surgery to save lives:            data from an international prospective cohort study. British Journal of Surgery, March 2021

 

13.   Determination of “borderline resectable” pancreatic cancer – a global assessment of 30 shades of grey. HPB, Manuscript               Number: HPB-D-23-00043R1 (Submitted June 2023)

 

14.   COVIDSurg3 Collaborative. Reducing the environmental impact of surgery on a global scale: systematic review and co-                   prioritization with healthcare workers in 132 countries. British Journal of Surgery, Volume 110, Issue 7, Pages 804–817, July           2023.  ​

 

15.   POSTVenTT Collaborative. The management of peri-operative anaemia in patients undergoing major abdominal surgery               in Australia and New Zealand: a prospective cohort study. Medical Journal of Australia, 217(9):487-493. doi:                                       10.5694/mja2.51725, Novemeber 2022.

16.   COVIDSurg Collaborative and GlobalSurg Collaborative. Timing of surgery following SARS-CoV-2 infection an international              prospective cohort study. Anaesthesia, March 2021.

         Authorship: https://biblio.ugent.be/publication/8699263/file/8699266.docx

17.    Gao N, Guest G, Thomson BN, Bozin M, Mann B, Tan S, Clark DA, Daruwalla J, et al., Laparoscopic or open appendicectomy

         for suspected appendicitis in pregnancy, evaluation of fetal outcome in Australia. ANZJS. Sept 6 Epub 2016

18.    Fifis T, Nguyen L, Malcontenti Wilson, Chan L, Costa P, Daruwalla J, Nikfarjam M, Muralidharan V, Waltham M, Thompson E            & Christophi C. Treatment with the vascular disruptive agent OXi4503 induces an immediate and widespread Epithelial to

         Mesenchymal Transition (EMT) in the surviving tumor, Cancer Medicine. 2(5): 595-610 2013

19.   Satasivam P, Lim M, Reeves F, Daruwalla J, Casan J, Lim C & Royce P. The effect of oral anticoagulation on the incidence and

        management of haematuria in a contemporary Australian patient cohort. British Journal of Urology International.

        110(Suppl 4): 80-84, 2012

20.   Maeda H, Bharate G, & Daruwalla J. Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect.

        European Journal of Pharmacy and Biopharmacy. 71(3): 409-419, 2009

21.   Chan LS, Daruwalla J & Christophi C. Selective targeting of the tumour vasculature. ANZ Journal of Surgery. 78(11): 955-967,

        2008

22.   Fifis T, Lam I, Malcontenti-Wilson C, Daruwalla J, Chan L, Harun N, Christophi C & Loveland B. Immunization with Heat-                  Stressed Tumour Cells Reduces Colorectal Cancer Liver Metastases. Tissue Antigens. 66 (5): 416-417, 2005.

23.   Nikfarjam M, Malcontenti-Wilson C, Fanartzis M, Daruwalla J, & Christophi C. A model of partial hepatectomy in mice.

         Journal of Investigative Surgery. 17(5): 291-294, 2004.

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